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Besides, HIF accumulation facilitates the secretion of several growth factors and further activates mTOR to form a positive feedback circuit

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Metabolic Pathway Analysis Metabolic pathway analysis was performed using the MetPA tool of MetaboAnalyst (v4.0, see footnote 1), in order to interpret the biological relevance of our findings from both PTC vs healthy groups, and MNG vs healthy groups, which integrates two pathway analyses approaches – enrichment and topology pathway analysis